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Int. J. Mol. Sci. 2016, 17(5), 744; doi:10.3390/ijms17050744

Postprandial C-Peptide to Glucose Ratio as a Marker of β Cell Function: Implication for the Management of Type 2 Diabetes

Department of Internal Medicine, Keio University School of Medicine, 1608582 Tokyo, Japan
Academic Editor: Toshiro Arai
Received: 30 March 2016 / Revised: 7 May 2016 / Accepted: 11 May 2016 / Published: 17 May 2016
(This article belongs to the Special Issue Molecular Research on Obesity and Diabetes)
View Full-Text   |   Download PDF [895 KB, uploaded 17 May 2016]   |  

Abstract

C-peptide is secreted from pancreatic β cells at an equimolar ratio to insulin. Since, in contrast to insulin, C-peptide is not extracted by the liver and other organs, C-peptide reflects endogenous insulin secretion more accurately than insulin. C-peptide is therefore used as a marker of β cell function. C-peptide has been mainly used to assess the presence of an insulin-dependent state for the diagnosis of type 1 diabetes. However, recent studies have revealed that β cell dysfunction is also a core deficit of type 2 diabetes, and residual β cell function is a key factor in achieving optimal glycemic control in patients with type 2 diabetes. This review summarizes the role of C-peptide, especially the postprandial C-peptide to glucose ratio which likely better reflects maximum β cell secretory capacity compared with the fasting ratio in assessing β cell function, and discusses perspectives on its clinical utility for managing glycemic control in patients with type 2 diabetes. View Full-Text
Keywords: C-peptide; type 2 diabetes; β cell function; postprandial C-peptide; type 2 diabetes; β cell function; postprandial
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Saisho, Y. Postprandial C-Peptide to Glucose Ratio as a Marker of β Cell Function: Implication for the Management of Type 2 Diabetes. Int. J. Mol. Sci. 2016, 17, 744.

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