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Int. J. Mol. Sci. 2016, 17(5), 627; doi:10.3390/ijms17050627

New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies

1
Molecular Oncology, Biodonostia Research Institute, 20014 San Sebastián, Spain
2
IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain
3
Hematology Department, Donostia Hospital, 20014 San Sebastián, Spain
4
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford OX3 9DU, UK
These authors contributed equally to this work.
Joint senior authors.
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 13 February 2016 / Revised: 18 April 2016 / Accepted: 18 April 2016 / Published: 27 April 2016
(This article belongs to the Special Issue Liquid Biopsy for Clinical Application)
View Full-Text   |   Download PDF [1845 KB, uploaded 27 April 2016]   |  

Abstract

The effective and efficient management of cancer patients relies upon early diagnosis and/or the monitoring of treatment, something that is often difficult to achieve using standard tissue biopsy techniques. Biological fluids such as blood hold great possibilities as a source of non-invasive cancer biomarkers that can act as surrogate markers to biopsy-based sampling. The non-invasive nature of these “liquid biopsies” ultimately means that cancer detection may be earlier and that the ability to monitor disease progression and/or treatment response represents a paradigm shift in the treatment of cancer patients. Below, we review one of the most promising classes of circulating cancer biomarkers: microRNAs (miRNAs). In particular, we will consider their history, the controversy surrounding their origin and biology, and, most importantly, the hurdles that remain to be overcome if they are really to become part of future clinical practice. View Full-Text
Keywords: miRNAs; cfmiRNAs; liquid biopsies miRNAs; cfmiRNAs; liquid biopsies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Larrea, E.; Sole, C.; Manterola, L.; Goicoechea, I.; Armesto, M.; Arestin, M.; Caffarel, M.M.; Araujo, A.M.; Araiz, M.; Fernandez-Mercado, M.; Lawrie, C.H. New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies. Int. J. Mol. Sci. 2016, 17, 627.

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