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Int. J. Mol. Sci. 2016, 17(4), 616; doi:10.3390/ijms17040616

Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence

1
Department of Chinese Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 600, Taiwan
2
Department of Life Science, National Chung Cheng University, Chiayi 621, Taiwan
3
Department of Nursing, Min-Hwei Junior College of Health Care Management, Tainan City 736, Taiwan
4
Graduate Institute of Clinical Medical Sciences, Chang Gung University, Chiayi 613, Taiwan
5
Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 600, Taiwan
6
Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
7
Division of Endocrinology and Metabolism, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 600, Taiwan
These authors contributed equally to this study.
*
Authors to whom correspondence should be addressed.
Academic Editors: Ge Zhang, Aiping Lu and Hailong Zhu
Received: 28 March 2016 / Revised: 19 April 2016 / Accepted: 20 April 2016 / Published: 23 April 2016
(This article belongs to the Special Issue Translational Molecular Medicine & Molecular Drug Discovery)
View Full-Text   |   Download PDF [3402 KB, uploaded 23 April 2016]   |  

Abstract

Oral squamous cell carcinoma (OSCC), an aggressive cancer originating in the oral cavity, is one of the leading causes of cancer deaths in males worldwide. This study investigated the antitumor activity and mechanisms of piperlongumine (PL), a natural compound isolated from Piper longum L., in human OSCC cells. The effects of PL on cell proliferation, the cell cycle, apoptosis, senescence and reactive oxygen species (ROS) levels in human OSCC cells were investigated. PL effectively inhibited cell growth, caused cell cycle arrest and induced apoptosis and senescence in OSCC cells. Moreover, PL-mediated anti-human OSCC behavior was inhibited by an ROS scavenger N-acetyl-l-cysteine (NAC) treatment, suggesting that regulation of ROS was involved in the mechanism of the anticancer activity of PL. These findings suggest that PL suppresses tumor growth by regulating the cell cycle and inducing apoptosis and senescence and is a potential chemotherapy agent for human OSCC cells. View Full-Text
Keywords: piperlongumine; human oral squamous cell carcinoma; cell cycle arrest; apoptosis; senescence piperlongumine; human oral squamous cell carcinoma; cell cycle arrest; apoptosis; senescence
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MDPI and ACS Style

Chen, S.-Y.; Liu, G.-H.; Chao, W.-Y.; Shi, C.-S.; Lin, C.-Y.; Lim, Y.-P.; Lu, C.-H.; Lai, P.-Y.; Chen, H.-R.; Lee, Y.-R. Piperlongumine Suppresses Proliferation of Human Oral Squamous Cell Carcinoma through Cell Cycle Arrest, Apoptosis and Senescence. Int. J. Mol. Sci. 2016, 17, 616.

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