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Int. J. Mol. Sci. 2016, 17(4), 553; doi:10.3390/ijms17040553

Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic

1
Oncology Research Unit, Oncology Hospital, National Medical Center, IMSS, Avenida Cuauhtémoc 330, Colonia Doctores, c.p. 06720 Mexico City, Mexico
2
Department of Pathology, Stanford University School of Medicine 300 Pasteur Dr., L235, Stanford, CA 94305, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Vivienne Rebel
Received: 7 March 2016 / Revised: 26 March 2016 / Accepted: 7 April 2016 / Published: 13 April 2016
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Myelodysplastic Syndrome)
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Abstract

We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we provide a model that incorporates in vitro and in vivo models as well as in situ findings from intact human marrow to explain the changes seen in myelodysplastic syndrome patients. We highlight the clinical application of the study of the bone marrow microenvironment and its topobiology in myelodysplastic syndromes. View Full-Text
Keywords: myelodysplasia; myelodysplastic syndromes; topobiology; niche; mesenchymal stem cells; macrophages myelodysplasia; myelodysplastic syndromes; topobiology; niche; mesenchymal stem cells; macrophages
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Flores-Figueroa, E.; Gratzinger, D. Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic. Int. J. Mol. Sci. 2016, 17, 553.

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