Next Article in Journal
Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet
Next Article in Special Issue
Toxic Effects of the Major Components of Diesel Exhaust in Human Alveolar Basal Epithelial Cells (A549)
Previous Article in Journal
Mesenchymal Stem Cells Ameliorated Glucolipotoxicity in HUVECs through TSG-6
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2016, 17(4), 485; doi:10.3390/ijms17040485

Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence?

1
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population & Global Health, the University of Melbourne, Melbourne, VIC 3053, Australia
2
Murdoch Childrens Research Institute, Melbourne, VIC 3052, Australia
3
School of Psychology & Public Health, Department of Public Health, Latrobe University, Melbourne, VIC 3086, Australia
4
School of Public Health & Preventive Medicine, Monash University, The Alfred, Melbourne, VIC 3004, Australia
5
Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW 2037, Australia
6
South Western Sydney Clinical School, University of New South Wales, Sydney, NSW 2052, Australia
7
Busselton Population Medical Research Institute, Perth WA 6009, Australia
8
Molecular Genetics of Lung Diseases, Comprehensive Pneumology Center, Helmholtz Zentrum, Muenchen 81377, Germany
9
Department of Allergy and Immunology, Royal Children’s Hospital, Parkville, VIC 3052, Australia
These authors equally contributed to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 3 March 2016 / Revised: 24 March 2016 / Accepted: 28 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Molecular Research on Global Climate Change and Atmospheric Pollution)
View Full-Text   |   Download PDF [1032 KB, uploaded 1 April 2016]   |  

Abstract

Polymorphisms in genes involved in the oxidative stress response may partially explain the documented heterogeneous associations between traffic-related air pollution (TRAP) exposure and asthma and allergies in children. We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence. We used a birth cohort of 620 high risk infants from the Melbourne Atopy Cohort Study. TRAP exposure during the first year of life was defined as the cumulative length of major roads within 150 m of each participant’s residence during the first year of life. Wheeze, asthma and hay fever were measured at ages 12 (n = 370) and 18 (n = 434) years. The associations and interactions with glutathione S-transferases (GST s) were investigated using regression models. Overall, there was no relationship between TRAP exposure during the first year of life and current asthma, wheeze and hay fever at ages 12 or 18 years. However, in GSTT1 null carriers, every 100 m increase in cumulative lengths of major road exposure during the first year of life was associated with a 2.31-fold increased risk of wheeze and a 2.15-fold increased risk of asthma at 12 years. TRAP is associated with some respiratory outcomes in carriers of genetic polymorphisms in oxidative stress metabolism genes. View Full-Text
Keywords: asthma; glutathione S-transferase; hay fever; traffic related air pollution; wheeze asthma; glutathione S-transferase; hay fever; traffic related air pollution; wheeze
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bowatte, G.; Lodge, C.J.; Lowe, A.J.; Erbas, B.; Dennekamp, M.; Marks, G.B.; Perret, J.; Hui, J.; Wjst, M.; Gurrin, L.C.; Allen, K.J.; Abramson, M.J.; Matheson, M.C.; Dharmage, S.C. Do Variants in GSTs Modify the Association between Traffic Air Pollution and Asthma in Adolescence? Int. J. Mol. Sci. 2016, 17, 485.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top