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Int. J. Mol. Sci. 2016, 17(3), 131; doi:10.3390/ijms17030131

Mycobacterium tuberculosis: Manipulator of Protective Immunity

Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa
Current address: Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
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Author to whom correspondence should be addressed.
Academic Editor: Susanna Esposito
Received: 17 November 2015 / Revised: 17 December 2015 / Accepted: 23 December 2015 / Published: 25 February 2016
View Full-Text   |   Download PDF [239 KB, uploaded 25 February 2016]   |  

Abstract

Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection. View Full-Text
Keywords: tuberculosis; mycobacterium; granuloma; foamy macrophage tuberculosis; mycobacterium; granuloma; foamy macrophage
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Korb, V.C.; Chuturgoon, A.A.; Moodley, D. Mycobacterium tuberculosis: Manipulator of Protective Immunity. Int. J. Mol. Sci. 2016, 17, 131.

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