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Int. J. Mol. Sci. 2016, 17(2), 195; doi:10.3390/ijms17020195

Radical-Mediated Enzymatic Polymerizations

Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI 48109, USA
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
Department of Chemical Engineering and Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI 48109, USA
Author to whom correspondence should be addressed.
Academic Editor: Vladimír Křen
Received: 9 January 2016 / Revised: 25 January 2016 / Accepted: 27 January 2016 / Published: 2 February 2016
(This article belongs to the Special Issue Molecular Biocatalysis)
View Full-Text   |   Download PDF [1925 KB, uploaded 2 February 2016]   |  


Polymerization reactions are commonly effected by exposing monomer formulations to some initiation stimulus such as elevated temperature, light, or a chemical reactant. Increasingly, these polymerization reactions are mediated by enzymes―catalytic proteins―owing to their reaction efficiency under mild conditions as well as their environmental friendliness. The utilization of enzymes, particularly oxidases and peroxidases, for generating radicals via reduction-oxidation mechanisms is especially common for initiating radical-mediated polymerization reactions, including vinyl chain-growth polymerization, atom transfer radical polymerization, thiol–ene step-growth polymerization, and polymerization via oxidative coupling. While enzyme-mediated polymerization is useful for the production of materials intended for subsequent use, it is especially well-suited for in situ polymerizations, where the polymer is formed in the place where it will be utilized. Such polymerizations are especially useful for biomedical adhesives and for sensing applications. View Full-Text
Keywords: polymerization; enzymes; oxidase; peroxidase; vinyl; thiol–ene; ATRP; oxidative coupling polymerization; enzymes; oxidase; peroxidase; vinyl; thiol–ene; ATRP; oxidative coupling

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Zavada, S.R.; Battsengel, T.; Scott, T.F. Radical-Mediated Enzymatic Polymerizations. Int. J. Mol. Sci. 2016, 17, 195.

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