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Int. J. Mol. Sci. 2016, 17(2), 183; doi:10.3390/ijms17020183

Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice

1,†
,
2,†
,
1,3
and
1,*
1
Department of Stem Cell Disorders, Kansai Medical University, Hirakata City, Osaka 573-1010, Japan
2
Department of Cardiac Surgery, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China
3
Division of Surgical Pathology, Toyooka Hospital, Hyogo 668-8501, Japan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Maurizio Muraca and Charles J. Malemud
Received: 10 December 2015 / Revised: 20 January 2016 / Accepted: 26 January 2016 / Published: 29 January 2016
(This article belongs to the Special Issue Advances in Cell Transplantation)
View Full-Text   |   Download PDF [1588 KB, uploaded 29 January 2016]   |  

Abstract

Senescence accelerated mice (SAM) are a group of mice that show aging-related diseases, and SAM prone 10 (SAMP10) show spontaneous brain atrophy and defects in learning and memory. Our previous report showed that the thymus and the percentage of T lymphocytes are abnormal in the SAMP10, but it was unclear whether the bone marrow-derived mesenchymal stroma cells (BMMSCs) were abnormal, and whether they played an important role in regenerative medicine. We thus compared BMMSCs from SAMP10 and their control, SAM-resistant (SAMR1), in terms of cell cycle, oxidative stress, and the expression of PI3K and mitogen-activated protein kinase (MAPK). Our cell cycle analysis showed that cell cycle arrest occurred in the G0/G1 phase in the SAMP10. We also found increased reactive oxygen stress and decreased PI3K and MAPK on the BMMSCs. These results suggested the BMMSCs were abnormal in SAMP10, and that this might be related to the immune system dysfunction in these mice. View Full-Text
Keywords: SAMP10; bone marrow-derived MSCs; cell cycle; PI3K; MAPK SAMP10; bone marrow-derived MSCs; cell cycle; PI3K; MAPK
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MDPI and ACS Style

Li, M.; Guo, K.; Adachi, Y.; Ikehara, S. Immune Dysfunction Associated with Abnormal Bone Marrow-Derived Mesenchymal Stroma Cells in Senescence Accelerated Mice. Int. J. Mol. Sci. 2016, 17, 183.

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