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Int. J. Mol. Sci. 2016, 17(12), 2108; doi:10.3390/ijms17122108

Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation

1
Department of Physics and Materials Science, City University of Hong Kong, Hong Kong, China
2
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China
3
State Key Laboratory in Marine Pollution, City University of Hong Kong, Hong Kong, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Juliette Legler
Received: 23 September 2016 / Revised: 1 December 2016 / Accepted: 9 December 2016 / Published: 15 December 2016
(This article belongs to the Special Issue Zebrafish: A Model for Toxicological Research)
View Full-Text   |   Download PDF [294 KB, uploaded 15 December 2016]

Abstract

Exposure to ionizing radiations (IRs) is ubiquitous in our environment and can be categorized into “targeted” effects and “non-targeted” effects. In addition to inducing deoxyribonucleic acid (DNA) damage, IR exposure leads to epigenetic alterations that do not alter DNA sequence. Using an appropriate model to study the biological effects of radiation is crucial to better understand IR responses as well as to develop new strategies to alleviate exposure to IR. Zebrafish, Danio rerio, is a scientific model organism that has yielded scientific advances in several fields and recent studies show the usefulness of this vertebrate model in radiation biology. This review briefly describes both “targeted” and “non-targeted” effects, describes the findings in radiation biology using zebrafish as a model and highlights the potential of zebrafish to assess the epigenetic effects of IR, including DNA methylation, histone modifications and miRNA expression. Other in vivo models are included to compare observations made with zebrafish, or to illustrate the feasibility of in vivo models when the use of zebrafish was unavailable. Finally, tools to study epigenetic modifications in zebrafish, including changes in genome-wide DNA methylation, histone modifications and miRNA expression, are also described in this review. View Full-Text
Keywords: zebrafish embryos; epigenetic effects; ionizing radiation zebrafish embryos; epigenetic effects; ionizing radiation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kong, E.Y.; Cheng, S.H.; Yu, K.N. Zebrafish as an In Vivo Model to Assess Epigenetic Effects of Ionizing Radiation. Int. J. Mol. Sci. 2016, 17, 2108.

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