Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation
Abstract
:1. Introduction
2. Release, Binding and Internalization Properties of sSortilin/NTSR3
2.1. Shedding
2.2. Binding of sSortilin/NTSR3 to a Specific Receptor Independent on the Epidermal Growth Factor Receptor (EGFR)
2.3. Internalization Properties of Sortilin/NTSR3
3. Signaling of sSortilin/NTSR3 in HT29 Cells
3.1. Calcium and Protein Kinase C (PKCα) Translocation
3.2. Focal Adhesion Kinase (FAK) Dependent Stimulation of the PI3 Kinase Pathway
4. Morphological Changes of HT29 Cells Induced by sSortilin/NTSR3
Cell Shape and Size, Cytoskeleton and Cell–Cell Junctions Modification
5. Cell–Cell and Cell–Matrix Junctions
5.1. Desmosomes Disruption
5.2. Modification of Cadherin and Integrins
5.3. Cancer Cell Detachment
6. Other Functions of sSortilin/NTSR3
Atherosclerosis and Depression
7. Conclusions
Acknowledgments
Conflicts of Interest
References
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Béraud-Dufour, S.; Devader, C.; Massa, F.; Roulot, M.; Coppola, T.; Mazella, J. Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation. Int. J. Mol. Sci. 2016, 17, 1860. https://doi.org/10.3390/ijms17111860
Béraud-Dufour S, Devader C, Massa F, Roulot M, Coppola T, Mazella J. Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation. International Journal of Molecular Sciences. 2016; 17(11):1860. https://doi.org/10.3390/ijms17111860
Chicago/Turabian StyleBéraud-Dufour, Sophie, Christelle Devader, Fabienne Massa, Morgane Roulot, Thierry Coppola, and Jean Mazella. 2016. "Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation" International Journal of Molecular Sciences 17, no. 11: 1860. https://doi.org/10.3390/ijms17111860