Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias
AbstractThe unfolded protein response (UPR) has been extensively investigated in neurological diseases and diabetes, while its function in heart disease is less well understood. Activated UPR participates in multiple cardiac conditions and can either protect or impair heart function. Recently, the UPR has been found to play a role in arrhythmogenesis during human heart failure by affecting cardiac ion channels expression, and blocking UPR has an antiarrhythmic effect. This review will discuss the rationale for and challenges to targeting UPR in heart disease for treatment of arrhythmias. View Full-Text
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Liu, M.; Dudley, S.C., Jr. Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias. Int. J. Mol. Sci. 2016, 17, 52.
Liu M, Dudley SC, Jr. Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias. International Journal of Molecular Sciences. 2016; 17(1):52.Chicago/Turabian Style
Liu, Man; Dudley, Samuel C., Jr. 2016. "Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias." Int. J. Mol. Sci. 17, no. 1: 52.
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