Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis †
Abstract
:1. Introduction
2. Enantiopure 2-Piperidineethanol: Resolution versus Synthesis
Enantiopure 2-Piperidineethanol by Enzymatic Kinetic Resolutions
3. An Overview of the Synthetic Strategies in the Synthesis of Alkaloids Starting from Either Enantiopure 1 or 2
3.1. Enantioselective Synthesis of the Alkaloid (+)-Aloperine
3.2. Enantioselective Synthesis of the Alkaloid Boehmeriasin A
3.3. Enantioselective Synthesis of the Alkaloid Dumetorine
3.4. Enantioselective Synthesis of the Alkaloids Sedamine, Allosedamine, Sedridines and Ethylnorlobelols
3.5. Synthesis of the Enantiopure Alkaloids Coniine and Epidihydropinidine
3.6. Enantioselective Synthesis of Polycyclic Piperidine Derivatives
4. A General Overview of the Structures of Alkaloids Synthesized from both 1 or 2
4.1. Enantioselective Synthesis of the Alkaloids (−)-Oncinotine, (−)-Isooncinotine, and (−)-Stellettamide B
4.2. Enantioselective Synthesis of the Alkaloids (+)-Vertine and (+)-Lythrine
4.3. Enantioselective Synthesis of the Alkaloids (+)-Myrtine, (−)-Lupinine, and (+)-Epiepiquinamide
4.4. Enantioselective Synthesis of the Alkaloids (−)-Cermizine C, (−)-Senepodine G and (+)-Cermizine D
4.5. Enantioselective Synthesis of the Alkaloids Psylloborine A and Isopsylloborine A
4.6. Enantioselective Synthesis of the Alkaloids Tetraponerines T3, T4, T7, and T8
4.7. Enantioselective Synthesis of the Alkaloids (+)-Conhydrine and 4-(2-(Piperidin-2-yl)ethoxy)quinoline Derivatives
5. Conclusions
Author Contributions
Conflicts of Interest
References
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Perdicchia, D.; Christodoulou, M.S.; Fumagalli, G.; Calogero, F.; Marucci, C.; Passarella, D. Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis. Int. J. Mol. Sci. 2016, 17, 17. https://doi.org/10.3390/ijms17010017
Perdicchia D, Christodoulou MS, Fumagalli G, Calogero F, Marucci C, Passarella D. Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis. International Journal of Molecular Sciences. 2016; 17(1):17. https://doi.org/10.3390/ijms17010017
Chicago/Turabian StylePerdicchia, Dario, Michael S. Christodoulou, Gaia Fumagalli, Francesco Calogero, Cristina Marucci, and Daniele Passarella. 2016. "Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis" International Journal of Molecular Sciences 17, no. 1: 17. https://doi.org/10.3390/ijms17010017