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Int. J. Mol. Sci. 2016, 17(1), 102; doi:10.3390/ijms17010102

Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization

Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim 68167, Germany
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Academic Editor: Terrence Piva
Received: 29 September 2015 / Revised: 22 December 2015 / Accepted: 25 December 2015 / Published: 14 January 2016
(This article belongs to the Collection Radiation Toxicity in Cells)
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Abstract

During the last few decades, improvements in the planning and application of radiotherapy in combination with surgery and chemotherapy resulted in increased survival rates of tumor patients. However, the success of radiotherapy is impaired by two reasons: firstly, the radioresistance of tumor cells and, secondly, the radiation-induced damage of normal tissue cells located in the field of ionizing radiation. These limitations demand the development of drugs for either radiosensitization of tumor cells or radioprotection of normal tissue cells. In order to identify potential targets, a detailed understanding of the cellular pathways involved in radiation response is an absolute requirement. This review describes the most important pathways of radioresponse and several key target proteins for radiosensitization. View Full-Text
Keywords: radiotherapy; radioresistance; radiosensitization; double strand break; DNA repair; apoptosis; mitotic catastrophe; senescence radiotherapy; radioresistance; radiosensitization; double strand break; DNA repair; apoptosis; mitotic catastrophe; senescence
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Maier, P.; Hartmann, L.; Wenz, F.; Herskind, C. Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization. Int. J. Mol. Sci. 2016, 17, 102.

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