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Int. J. Mol. Sci. 2015, 16(9), 22830-22855; doi:10.3390/ijms160922830

Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach

1
and
1,2,*
1
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Ya’an 625014, China
2
College of Veterinary Medicine, Sichuan Agricultural University, Ya’an 625014, China
*
Author to whom correspondence should be addressed.
Academic Editor: Anthony Lemarié
Received: 23 August 2015 / Revised: 11 September 2015 / Accepted: 15 September 2015 / Published: 22 September 2015
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
View Full-Text   |   Download PDF [1046 KB, uploaded 22 September 2015]   |  

Abstract

Glutamine metabolism has been proved to be dysregulated in many cancer cells, and is essential for proliferation of most cancer cells, which makes glutamine an appealing target for cancer therapy. In order to be well used by cells, glutamine must be transported to cells by specific transporters and converted to glutamate by glutaminase. There are currently several drugs that target glutaminase under development or clinical trials. Also, glutamine metabolism restriction has been proved to be effective in inhibiting tumor growth both in vivo and vitro through inducing apoptosis, growth arrest and/or autophagy. Here, we review recent researches about glutamine metabolism in cancer, and cell death induced by targeting glutamine, and their potential roles in cancer therapy. View Full-Text
Keywords: glutamine metabolism; apoptosis; glutaminase; cancer glutamine metabolism; apoptosis; glutaminase; cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chen, L.; Cui, H. Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach. Int. J. Mol. Sci. 2015, 16, 22830-22855.

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