Next Article in Journal
Local Controlled Release of Polyphenol Conjugated with Gelatin Facilitates Bone Formation
Previous Article in Journal
Novel Therapeutic GPCRs for Psychiatric Disorders
Previous Article in Special Issue
Gene Expression Signature in Endemic Osteoarthritis by Microarray Analysis
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2015, 16(6), 14122-14142; doi:10.3390/ijms160614122

Circulating Cell-Free Tumour DNA in the Management of Cancer

1
Director Pathology, Genomics for Life, Herston 4006, Australia
2
School of Medicine, Griffith University, Gold Coast 4215, Australia
3
Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia 4067, Australia
4
Laboratory Director, Genomics for Life, Herston 4006, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Camile S. Farah
Received: 22 February 2015 / Revised: 23 April 2015 / Accepted: 26 May 2015 / Published: 19 June 2015
(This article belongs to the Special Issue Emerging Classes of Biomarkers for Molecular Diagnostics)
View Full-Text   |   Download PDF [737 KB, uploaded 19 June 2015]   |  

Abstract

With the development of new sensitive molecular techniques, circulating cell-free tumour DNA containing mutations can be identified in the plasma of cancer patients. The applications of this technology may result in significant changes to the care and management of cancer patients. Whilst, currently, these “liquid biopsies” are used to supplement the histological diagnosis of cancer and metastatic disease, in the future these assays may replace the need for invasive procedures. Applications include the monitoring of tumour burden, the monitoring of minimal residual disease, monitoring of tumour heterogeneity, monitoring of molecular resistance and early diagnosis of tumours and metastatic disease. View Full-Text
Keywords: cell-free DNA; cell-free tumour DNA; non-small cell lung cancer; melanoma; colorectal carcinoma; minimal residual disease; liquid biopsy cell-free DNA; cell-free tumour DNA; non-small cell lung cancer; melanoma; colorectal carcinoma; minimal residual disease; liquid biopsy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Francis, G.; Stein, S. Circulating Cell-Free Tumour DNA in the Management of Cancer. Int. J. Mol. Sci. 2015, 16, 14122-14142.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top