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Int. J. Mol. Sci. 2015, 16(6), 12648-12668; doi:10.3390/ijms160612648

Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases

1
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstańców Wlkp. 72 Av., 70-111 Szczecin, Poland
2
Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24 Str., 71-460 Szczecin, Poland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kaixun Huang
Received: 14 April 2015 / Revised: 12 May 2015 / Accepted: 19 May 2015 / Published: 4 June 2015
(This article belongs to the Special Issue Applied Bioinorganic Chemistry and Selected Papers from 13th ISABC)
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Abstract

This paper discusses how the activity and expression of cyclooxygenases are influenced by vanadium compounds at anticancer concentrations and recorded in inorganic vanadium poisonings. We refer mainly to the effects of vanadate (orthovanadate), vanadyl and pervanadate ions; the main focus is placed on their impact on intracellular signaling. We describe the exact mechanism of the effect of vanadium compounds on protein tyrosine phosphatases (PTP), epidermal growth factor receptor (EGFR), PLCγ, Src, mitogen-activated protein kinase (MAPK) cascades, transcription factor NF-κB, the effect on the proteolysis of COX-2 and the activity of cPLA2. For a better understanding of these processes, a lot of space is devoted to the transformation of vanadium compounds within the cell and the molecular influence on the direct targets of the discussed vanadium compounds. View Full-Text
Keywords: vanadium; tyrosine phosphatase; cell signaling; cyclooxygenase vanadium; tyrosine phosphatase; cell signaling; cyclooxygenase
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Korbecki, J.; Baranowska-Bosiacka, I.; Gutowska, I.; Chlubek, D. Vanadium Compounds as Pro-Inflammatory Agents: Effects on Cyclooxygenases. Int. J. Mol. Sci. 2015, 16, 12648-12668.

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