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Int. J. Mol. Sci. 2015, 16(5), 9866-9895; doi:10.3390/ijms16059866

Structural Insights into tRNA Dynamics on the Ribosome

Structural Biology Unit, CICbioGUNE Biscay Technology Park, Bld 800, 48610 Derio, Basque Country, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Michael Ibba
Received: 27 March 2015 / Revised: 21 April 2015 / Accepted: 22 April 2015 / Published: 30 April 2015
(This article belongs to the Special Issue Functions of Transfer RNAs)
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Abstract

High-resolution structures at different stages, as well as biochemical, single molecule and computational approaches have highlighted the elasticity of tRNA molecules when bound to the ribosome. It is well acknowledged that the inherent structural flexibility of the tRNA lies at the heart of the protein synthesis process. Here, we review the recent advances and describe considerations that the conformational changes of the tRNA molecules offer about the mechanisms grounded in translation. View Full-Text
Keywords: ribosome; tRNA dynamics; protein synthesis; structure; conformational landscape ribosome; tRNA dynamics; protein synthesis; structure; conformational landscape
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Agirrezabala, X.; Valle, M. Structural Insights into tRNA Dynamics on the Ribosome. Int. J. Mol. Sci. 2015, 16, 9866-9895.

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