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Int. J. Mol. Sci. 2015, 16(4), 7413-7427; doi:10.3390/ijms16047413

The Relevance of miRNA-21 in HSV-Induced Inflammation in a Mouse Model

1
Department of Microbiology, Ajou University School of Medicine, Suwon 443-380, Korea
2
Department of Rheumatology, Ajou University School of Medicine, Suwon 443-380, Korea
3
Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 443-380, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Received: 22 December 2014 / Revised: 26 March 2015 / Accepted: 30 March 2015 / Published: 2 April 2015
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Abstract

The purpose of this study was to clarify the correlation between microRNA-21 (miR-21) expression and inflammation in a herpes simplex virus (HSV)-induced Behçet’s Disease (BD) mouse model. miR-21 was compared between BD patients and healthy controls in peripheral blood mononuclear cells (PBMC). For miR-21 inhibition, miR-21 antagomir was applied to BD mice. The change of symptoms was monitored. The levels of cytokines and related molecules were determined by ELISA and real time qPCR. Treatment with colchicine or pentoxifylline down-regulated the level of miR-21 with improved symptoms in mice. miR-21 inhibition was accompanied by down-regulated serum levels of IL-17 and IL-6. The expression levels of PDCD4, RhoB, PD-1, IL-12p35, and toll-like receptor-4 were also regulated by miR-21 inhibition. miR-21 was correlated with HSV-induced BD-like inflammation in mice and BD patients. The expression of miR-21 was regulated by antagomir in mice. View Full-Text
Keywords: microRNA-21; herpes simplex virus-induced inflammation; mouse model; Behçet’s Disease; miR-21 antagomir microRNA-21; herpes simplex virus-induced inflammation; mouse model; Behçet’s Disease; miR-21 antagomir
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choi, B.; Kim, H.-A.; Suh, C.-H.; Byun, H.O.; Jung, J.-Y.; Sohn, S. The Relevance of miRNA-21 in HSV-Induced Inflammation in a Mouse Model. Int. J. Mol. Sci. 2015, 16, 7413-7427.

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