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Int. J. Mol. Sci. 2015, 16(3), 6337-6352; doi:10.3390/ijms16036337

Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action

1
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Caixa Postal 26077, CEP 05513-970 São Paulo, Brazil
2
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, CEP 05508-900 São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: John George Hardy
Received: 27 February 2015 / Revised: 12 March 2015 / Accepted: 16 March 2015 / Published: 19 March 2015
(This article belongs to the Special Issue Supramolecular Interactions)
View Full-Text   |   Download PDF [6024 KB, uploaded 19 March 2015]   |  

Abstract

The growing challenge of antimicrobial resistance to antibiotics requires novel synthetic drugs or new formulations for old drugs. Here, cationic nanostructured particles (NPs) self-assembled from cationic bilayer fragments and polyelectrolytes are tested against four multidrug-resistant (MDR) strains of clinical importance. The non-hemolytic poly(diallyldimethylammonium) chloride (PDDA) polymer as the outer NP layer shows a remarkable activity against these organisms. The mechanism of cell death involves bacterial membrane lysis as determined from the leakage of inner phosphorylated compounds and possibly disassembly of the NP with the appearance of multilayered fibers made of the NP components and the biopolymers withdrawn from the cell wall. The NPs display broad-spectrum activity against MDR microorganisms, including Gram-negative and Gram-positive bacteria and yeast. View Full-Text
Keywords: multidrug-resistant microbes; viable cells counting; broad-spectrum and antimicrobial activity; biocompatible cationic polymer; self-assembled; cationic and hybrid nanoparticles; nanoparticles disassembly; leakage of intracellular compounds; damage to the cell wall; scanning electron microscopy multidrug-resistant microbes; viable cells counting; broad-spectrum and antimicrobial activity; biocompatible cationic polymer; self-assembled; cationic and hybrid nanoparticles; nanoparticles disassembly; leakage of intracellular compounds; damage to the cell wall; scanning electron microscopy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

de Melo Carrasco, L.D.; Sampaio, J.L.M.; Carmona-Ribeiro, A.M. Supramolecular Cationic Assemblies against Multidrug-Resistant Microorganisms: Activity and Mechanism of Action. Int. J. Mol. Sci. 2015, 16, 6337-6352.

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