Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes
Abstract
:1. Introduction
2. Results
2.1. Hypoxia Exacerbates Growth Suppression in Hepatocytes Treated with Palmitic Acid (PA)
2.2. Hypoxia Exacerbates Lipoapoptosis Occurring via Mitochondrial Pathways
2.3. Hypoxia Exacerbates Endoplasmic Reticulum Stress Leading to Activation of Mitochondrial Apoptotic Pathways
2.4. Reduction of Oxidative Stress Attenuates Exacerbation of Lipoapoptosis by Hypoxia
3. Discussion
4. Materials and Methods
4.1. Cell Lines and Culture
4.2. Cell Proliferation Analysis
4.3. Reagents
4.4. Apoptosis Analysis
4.5. Immunoblot Analysis
4.6. Data Analysis
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Hwang, S.Y.; Yu, S.J.; Lee, J.-H.; Kim, H.Y.; Kim, Y.J. Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes. Int. J. Mol. Sci. 2015, 16, 3323-3334. https://doi.org/10.3390/ijms16023323
Hwang SY, Yu SJ, Lee J-H, Kim HY, Kim YJ. Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes. International Journal of Molecular Sciences. 2015; 16(2):3323-3334. https://doi.org/10.3390/ijms16023323
Chicago/Turabian StyleHwang, Sang Youn, Su Jong Yu, Jeong-Hoon Lee, Hwi Young Kim, and Yoon Jun Kim. 2015. "Reduction of Oxidative Stress Attenuates Lipoapoptosis Exacerbated by Hypoxia in Human Hepatocytes" International Journal of Molecular Sciences 16, no. 2: 3323-3334. https://doi.org/10.3390/ijms16023323