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Int. J. Mol. Sci. 2015, 16(12), 29219-29225; doi:10.3390/ijms161226160

Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma

1
Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy
2
Urology Unit, ICOT, Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy
3
Department of Anatomical, Histological, Forensic & Orthopaedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome 00161, Italy
4
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina 04100, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: William Chi-shing Cho and Nalini Santanam
Received: 5 October 2015 / Revised: 26 November 2015 / Accepted: 30 November 2015 / Published: 8 December 2015
(This article belongs to the Special Issue MicroRNA in Various Disease States as Biomarkers)
View Full-Text   |   Download PDF [427 KB, uploaded 8 December 2015]   |  

Abstract

A key challenge for the improvement of clear cell renal cell carcinoma (ccRCC) management could derive from a deeper characterization of the biology of these neoplasms that could greatly improve the diagnosis, prognosis and treatment choice. The aim of this study was to identify specific miRNAs that are deregulated in tumor vs. normal kidney tissues and that could impact on the biology of ccRCC. To this end we selected four miRNAs (miR-21-5p, miR-210-3p, miR-185-5p and miR-221-3p) and their expression has been evaluated in a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissues from 20 ccRCC patients who underwent surgical nephrectomy resection. miR-21-5p and miR-210-3p resulted the most significantly up-regulated miRNAs in this patient cohort, highlighting these onco-miRNAs as possible relevant players involved in ccRCC tumorigenesis. Thus, this study reports the identification of specific oncogenic miRNAs that are altered in ccRCC tissues and suggests that they might be useful biomarkers in ccRCC management. View Full-Text
Keywords: microRNAs; clear cell renal cell carcinoma; miR-21-5p and miR-210-3p microRNAs; clear cell renal cell carcinoma; miR-21-5p and miR-210-3p
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Petrozza, V.; Carbone, A.; Bellissimo, T.; Porta, N.; Palleschi, G.; Pastore, A.L.; Di Carlo, A.; Della Rocca, C.; Fazi, F. Oncogenic MicroRNAs Characterization in Clear Cell Renal Cell Carcinoma. Int. J. Mol. Sci. 2015, 16, 29219-29225.

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