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Int. J. Mol. Sci. 2015, 16(12), 29029-29046; doi:10.3390/ijms161226141

Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective

1
Department of Pathology, University of Otago, Dunedin 9054, New Zealand
2
Department of Anatomy, Brain Health Research Centre and Brain Research New Zealand, University of Otago, P.O. Box 913, Dunedin 9054, New Zealand
3
Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia
*
Author to whom correspondence should be addressed.
Academic Editors: Chris Sobey and Hyun Ah Kim
Received: 14 October 2015 / Revised: 24 November 2015 / Accepted: 25 November 2015 / Published: 4 December 2015
(This article belongs to the Special Issue The Immune System and Inflammation in Cerebral Ischemia)
View Full-Text   |   Download PDF [1370 KB, uploaded 4 December 2015]   |  

Abstract

Stroke is one of the leading causes of death and long-term disability, with limited treatment options available. Inflammation contributes to damage tissue in the central nervous system across a broad range of neuropathologies, including Alzheimer’s disease, pain, Schizophrenia, and stroke. While the immune system plays an important role in contributing to brain damage produced by ischemia, the damaged brain, in turn, can exert a powerful immune-suppressive effect that promotes infections and threatens the survival of stroke patients. Recently the cholinergic anti-inflammatory pathway, in particular its modulation using α7-nicotinic acetylcholine receptor (α7-nAChR) ligands, has shown potential as a strategy to dampen the inflammatory response and facilitate functional recovery in stroke patients. Here we discuss the current literature on stroke-induced inflammation and the effects of α7-nAChR modulators on innate immune cells. View Full-Text
Keywords: stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells stroke; inflammation; nicotinic; nicotinic acetylcholine receptor agonist; immune response; myeloid cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Neumann, S.; Shields, N.J.; Balle, T.; Chebib, M.; Clarkson, A.N. Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective. Int. J. Mol. Sci. 2015, 16, 29029-29046.

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