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Int. J. Mol. Sci. 2015, 16(12), 28218-28229; doi:10.3390/ijms161226092

Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation

1
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 150 Yagotoyama, Tenpaku-ku, Nagoya 468-8503, Japan
2
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Kenji Hashimoto
Received: 28 October 2015 / Revised: 17 November 2015 / Accepted: 20 November 2015 / Published: 27 November 2015
View Full-Text   |   Download PDF [693 KB, uploaded 27 November 2015]   |  

Abstract

Increasing epidemiological evidence indicates that perinatal infection with various viral pathogens enhances the risk for several psychiatric disorders. The pathophysiological significance of astrocyte interactions with neurons and/or gut microbiomes has been reported in neurodevelopmental disorders triggered by pre- and postnatal immune insults. Recent studies with the maternal immune activation or neonatal polyriboinosinic polyribocytidylic acid models of neurodevelopmental disorders have identified various candidate molecules that could be responsible for brain dysfunction. Here, we review the functions of several candidate molecules in neurodevelopment and brain function and discuss their potential as therapeutic targets for psychiatric disorders. View Full-Text
Keywords: schizophrenia; autism; animal model; polyI:C; astrocyte; interleukin-6; interferon-induced transmembrane 3; matrix metalloproteinase 3; gut microbiome schizophrenia; autism; animal model; polyI:C; astrocyte; interleukin-6; interferon-induced transmembrane 3; matrix metalloproteinase 3; gut microbiome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ibi, D.; Yamada, K. Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation. Int. J. Mol. Sci. 2015, 16, 28218-28229.

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