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Int. J. Mol. Sci. 2015, 16(11), 27824-27834; doi:10.3390/ijms161126060

Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma

1
Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, Japan
2
Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School Singapore, Singapore 169857, Singapore
3
Department of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation For Cancer Research (JFCR), Tokyo 135-8550, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Alan C. Leonard
Received: 3 September 2015 / Revised: 6 November 2015 / Accepted: 16 November 2015 / Published: 24 November 2015
(This article belongs to the Special Issue Molecular Machinery of Cell Growth Regulation)
View Full-Text   |   Download PDF [676 KB, uploaded 25 November 2015]   |  

Abstract

Esophageal cancer is one of the most common cancers worldwide. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in Eastern Asian countries. Several types of noncoding RNAs (ncRNAs) function as key epigenetic regulators of gene expression and are implicated in various physiological processes. Unambiguous evidence indicates that dysregulation of ncRNAs is deeply implicated in carcinogenesis, cancer progression and metastases of various cancers, including ESCC. The current review summarizes recent findings on the ncRNA-mediated mechanisms underlying the characteristic behaviors of ESCC that will help support the development of biomarkers and the design of novel therapeutic strategies. View Full-Text
Keywords: esophageal squamous cell carcinoma; microRNA; long noncoding RNA; cancer initiation; cancer development; biomarker esophageal squamous cell carcinoma; microRNA; long noncoding RNA; cancer initiation; cancer development; biomarker
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Sugihara, H.; Ishimoto, T.; Miyake, K.; Izumi, D.; Baba, Y.; Yoshida, N.; Watanabe, M.; Baba, H. Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma. Int. J. Mol. Sci. 2015, 16, 27824-27834.

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