Next Article in Journal
Metabolite Profile of Cervicovaginal Fluids from Early Pregnancy Is Not Predictive of Spontaneous Preterm Birth
Next Article in Special Issue
Therapeutic Potential of Cell Penetrating Peptides (CPPs) and Cationic Polymers for Chronic Hepatitis B
Previous Article in Journal
Safety Profile of TiO2-Based Photocatalytic Nanofabrics for Indoor Formaldehyde Degradation
Previous Article in Special Issue
Cell-Penetrating Ability of Peptide Hormones: Key Role of Glycosaminoglycans Clustering
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2015, 16(11), 27730-27740; doi:10.3390/ijms161126054

Biodistribution, Stability, and Blood Distribution of the Cell Penetrating Peptide Maurocalcine in Mice

1
Grenoble Alpes University, 38041 Saint-Martin-d'Hères, France
2
Radiopharmaceutiques Biocliniques, INSERM, UMR S1039, 38700 La Tronche, France
3
Smartox Biotechnologies, Bâtiment Nanobio, 570 rue de la Chimie, 38400 Saint Martin d’Hères, France
4
Science and Therapeutics, LabEx Ion Channels, Grenoble Institute of Neuroscience, INSERM, U836, 38700 La Tronche, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jagdish Singh
Received: 27 August 2015 / Revised: 22 October 2015 / Accepted: 22 October 2015 / Published: 19 November 2015
(This article belongs to the Special Issue Cell-Penetrating Peptides)
View Full-Text   |   Download PDF [2177 KB, uploaded 20 November 2015]   |  

Abstract

Maurocalcine (MCa) is the first natural cell penetrating peptide to be discovered in animal venom. In addition to the fact that it represents a potent vector for the cell penetration of structurally diverse therapeutic compounds, MCa also displays several distinguishing features that make it a potential peptide of choice for clinical and biotechnological applications. The aim of the present study was to gain new information about the properties of MCa in vivo in order to delineate the future potential applications of this vector. For this purpose, two analogues of this peptide with (Tyr-MCa) and without (Lin-Tyr-MCa) disulfide bridges were synthesized, radiolabeled with 125I, and their in vitro stabilities were first evaluated in mouse blood. The results indicated that 125I-Tyr-MCa was stable in vitro and that the disulfide bridges conferred a competitive advantage for the stability of peptide. Following in vivo injection in mice, 125I-Tyr-MCa targeted peripheral organs with interesting quantitative differences and the main route of peptide elimination was renal. View Full-Text
Keywords: maurocalcine; cell-penetrating peptide; in vivo biodistribution; drug delivery; blood stability maurocalcine; cell-penetrating peptide; in vivo biodistribution; drug delivery; blood stability
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Perret, P.; Ahmadi, M.; Riou, L.; Bacot, S.; Pecher, J.; Poillot, C.; Broisat, A.; Ghezzi, C.; De Waard, M. Biodistribution, Stability, and Blood Distribution of the Cell Penetrating Peptide Maurocalcine in Mice. Int. J. Mol. Sci. 2015, 16, 27730-27740.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top