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Int. J. Mol. Sci. 2015, 16(11), 27362-27370; doi:10.3390/ijms161126029

Three Peptides from Soy Glycinin Modulate Glucose Metabolism in Human Hepatic HepG2 Cells

Department of Pharmaceutical Sciences, University of Milan, Mangiagalli Street 25, 20133 Milan, Italy
Author to whom correspondence should be addressed.
Academic Editors: Gopinadhan Paliyath and Antonio Segura-Carretero
Received: 10 August 2015 / Revised: 4 November 2015 / Accepted: 5 November 2015 / Published: 16 November 2015
(This article belongs to the Special Issue The Mechanism of Action of Food Components in Disease Prevention)
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Ile-Ala-Val-Pro-Gly-Glu-Val-Ala (IAVPGEVA), Ile-Ala-Val-Pro-Thr-Gly-Val-Ala (IAVPTGVA) and Leu-Pro-Tyr-Pro (LPYP), three peptides deriving from soy glycinin hydrolysis, are known to regulate cholesterol metabolism in human hepatic HepG2 cells. We have recently demonstrated that the mechanism of action involves the activation of adenosine monophosphate-activated protein kinase (AMPK). This fact suggested a potential activity of the same peptides on glucose metabolism that prompted us to also investigate this aspect in the same cells. After treatment with IAVPGEVA, IAVPTGVA and LPYP, HepG2 cells were analyzed using a combination of molecular techniques, including western blot analysis, glucose uptake experiments and fluorescence microscopy evaluation. The results showed that these peptides are indeed able to enhance the capacity of HepG2 cells to uptake glucose, via glucose transporter 1 GLUT1 and glucose transporter 4 GLUT4 activation, through the stimulation of protein kinase B Akt and adenosine monophosphate-activated protein kinase AMPK pathways, both involved in glucose metabolism. View Full-Text
Keywords: bioactive peptides; functional foods; glucose uptake; HepG2 cell line; plant proteins bioactive peptides; functional foods; glucose uptake; HepG2 cell line; plant proteins

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lammi, C.; Zanoni, C.; Arnoldi, A. Three Peptides from Soy Glycinin Modulate Glucose Metabolism in Human Hepatic HepG2 Cells. Int. J. Mol. Sci. 2015, 16, 27362-27370.

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