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Int. J. Mol. Sci. 2015, 16(11), 26797-26812; doi:10.3390/ijms161125990

The Function of Autophagy in Neurodegenerative Diseases

School of Pharmaceutical Sciences, Tokushima Bunri University, Shido 1314-1, Sanuki, Kagawa 769-2193, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Kurt A. Jellinger
Received: 27 September 2015 / Revised: 30 October 2015 / Accepted: 2 November 2015 / Published: 9 November 2015
(This article belongs to the Special Issue Mechanisms of Neurodegeneration)
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Abstract

Macroautophagy, hereafter referred to as autophagy, is a bulk degradation process performed by lysosomes in which aggregated and altered proteins as well as dysfunctional organelles are decomposed. Autophagy is a basic cellular process that maintains homeostasis and is crucial for postmitotic neurons. Thus, impaired autophagic processes in neurons lead to improper homeostasis and neurodegeneration. Recent studies have suggested that impairments of the autophagic process are associated with several neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and static encephalopathy of childhood with neurodegeneration in adulthood. In this review, we focus on the recent findings regarding the autophagic process and the involvement of autophagy in neurodegenerative diseases. View Full-Text
Keywords: autophagy; mitophagy; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; ALS; SENDA autophagy; mitophagy; Alzheimer’s disease; Parkinson’s disease; Huntington’s disease; ALS; SENDA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kiriyama, Y.; Nochi, H. The Function of Autophagy in Neurodegenerative Diseases. Int. J. Mol. Sci. 2015, 16, 26797-26812.

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