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Int. J. Mol. Sci. 2015, 16(11), 26543-26554; doi:10.3390/ijms161125970

Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region

Department of Genetics and Institute of Biomedicine, University of Barcelona, Barcelona E-08028, Catalonia, Spain
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Author to whom correspondence should be addressed.
Academic Editor: Francesc Cebrià
Received: 20 September 2015 / Revised: 26 October 2015 / Accepted: 28 October 2015 / Published: 5 November 2015
(This article belongs to the Special Issue Molecular and Cellular Basis of Regeneration and Tissue Repair)
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Abstract

The wnt signaling pathway is an intercellular communication mechanism essential in cell-fate specification, tissue patterning and regional-identity specification. A βcatenin-dependent signal specifies the AP (Anteroposterior) axis of planarians, both during regeneration of new tissues and during normal homeostasis. Accordingly, four wnts (posterior wnts) are expressed in a nested manner in central and posterior regions of planarians. We have analyzed the specific role of each posterior wnt and the possible cooperation between them in specifying and patterning planarian central and posterior regions. We show that each posterior wnt exerts a distinct role during re-specification and maintenance of the central and posterior planarian regions, and that the integration of the different wnt signals (βcatenin dependent and independent) underlies the patterning of the AP axis from the central region to the tip of the tail. Based on these findings and data from the literature, we propose a model for patterning the planarian AP axis. View Full-Text
Keywords: patterning; identity specification; wnt signaling; planarians patterning; identity specification; wnt signaling; planarians
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sureda-Gómez, M.; Pascual-Carreras, E.; Adell, T. Posterior Wnts Have Distinct Roles in Specification and Patterning of the Planarian Posterior Region. Int. J. Mol. Sci. 2015, 16, 26543-26554.

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