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Int. J. Mol. Sci. 2015, 16(11), 26202-26210; doi:10.3390/ijms161125947

Characterization of Chitosan Nanofiber Sheets for Antifungal Application

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8552, Japan
Faculty of Agriculture, Tottori University, 4-101 Koyama-cho Minami, Tottori 680-8553, Japan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Hitoshi Sashiwa
Received: 29 September 2015 / Revised: 23 October 2015 / Accepted: 26 October 2015 / Published: 2 November 2015
(This article belongs to the Special Issue Chitins 2015)
View Full-Text   |   Download PDF [1511 KB, uploaded 2 November 2015]   |  


Chitosan produced by the deacetylation of chitin is a cationic polymer with antimicrobial properties. In this study, we demonstrate the improvement of chitosan properties by nanofibrillation. Nanofiber sheets were prepared from nanofibrillated chitosan under neutral conditions. The Young’s modulus and tensile strength of the chitosan NF sheets were higher than those of the chitosan sheets prepared from dissolving chitosan in acetic acid. The chitosan NF sheets showed strong mycelial growth inhibition against dermatophytes Microsporum and Trichophyton. Moreover, the chitosan NF sheets exhibited resistance to degradation by the fungi, suggesting potentials long-lasting usage. In addition, surface-deacetylated chitin nanofiber (SDCNF) sheets were prepared. The SDCNF sheet had a high Young’s modulus and tensile strength and showed antifungal activity to dermatophytes. These data indicate that nanofibrillation improved the properties of chitosan. Thus, chitosan NF and SDCNF sheets are useful candidates for antimicrobial materials. View Full-Text
Keywords: chitosan nanofibers; surface-deacetylated chitin nanofibers; antifungal activity; dermatophyte chitosan nanofibers; surface-deacetylated chitin nanofibers; antifungal activity; dermatophyte

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Egusa, M.; Iwamoto, R.; Izawa, H.; Morimoto, M.; Saimoto, H.; Kaminaka, H.; Ifuku, S. Characterization of Chitosan Nanofiber Sheets for Antifungal Application. Int. J. Mol. Sci. 2015, 16, 26202-26210.

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