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Int. J. Mol. Sci. 2015, 16(10), 23668-23682; doi:10.3390/ijms161023668

MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD

Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China
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Author to whom correspondence should be addressed.
Academic Editor: Y-h. Taguchi
Received: 7 July 2015 / Revised: 24 August 2015 / Accepted: 1 September 2015 / Published: 6 October 2015
(This article belongs to the Special Issue MicroRNA Regulation)
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Abstract

MiR-302b is a member of miR-302-367 cluster. The miR-302-367 cluster played important roles in maintaining pluripotency in human embryonic stem cells (hESCs) and has been proved to be capable of suppressing cell growth in several types of cancer cell lines including Hepatocellular Carcinoma (HCC) Cell lines. However, the role that miR-302b plays in the 5-Fluorouracil (5-FU) sensitivity of HCC has not been known. This study showed that miR-302b could enhance the sensitivity to 5-FU in HCC cell lines and verified its two putative targeted genes responsible for its 5-FU sensitivity. View Full-Text
Keywords: miR-302b; 5-Fluorouracil (5-FU); sensitivity; hepatocellular carcinoma cell lines miR-302b; 5-Fluorouracil (5-FU); sensitivity; hepatocellular carcinoma cell lines
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cai, D.; He, K.; Chang, S.; Tong, D.; Huang, C. MicroRNA-302b Enhances the Sensitivity of Hepatocellular Carcinoma Cell Lines to 5-FU via Targeting Mcl-1 and DPYD. Int. J. Mol. Sci. 2015, 16, 23668-23682.

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