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Int. J. Mol. Sci. 2014, 15(8), 14058-14076; doi:10.3390/ijms150814058

Association between Phosphatase Related Gene Variants and Coronary Artery Disease: Case-Control Study and Meta-Analysis

1
Department of Cardiology, Laiwu People's Hospital, Laiwu 271100, China
2
Department of Cardiology, Shandong Provincial Hospital, Jinan 250000, China
3
Department of Cardiology, Yantai Yuhuangding Hospital, Yantai 264000, China
*
Author to whom correspondence should be addressed.
Received: 5 June 2014 / Revised: 21 July 2014 / Accepted: 30 July 2014 / Published: 13 August 2014
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Recent studies showed that the serum alkaline phosphatase is an independent predictor of the coronary artery disease (CAD). In this work, we aimed to summarize the association between three phosphatase related single nucleotide polymorphisms (rs12526453, rs11066301 and rs3828329) and the risk of CAD in Han Chinese. Our results showed that the rs3828329 of the ACP1 gene was closely related to the risk of CAD in Han Chinese (OR = 1.45, p = 0.0006). This significant association of rs3828329 with CAD was only found in the females (Additive model: OR = 1.80, p = 0.001; dominant model: OR = 1.69, p = 0.03; recessive model: OR = 1.96, p = 0.0008). Moreover, rs3828329 was likely to exert its effect in females aged 65 years and older (OR = 2.27, p = 0.001). Further meta-analyses showed that the rs12526453 of PHACTR11 gene (OR = 1.14, p < 0.0001, random-effect method) and the rs11066301 of PTPN11 gene (OR = 1.15, p < 0.0001, fixed-effects method) were associated with CAD risk in multiple populations. Our results showed that the polymorphisms rs12526453 and rs11066301 are significantly associated with the CAD risk in multiple populations. The rs3828329 of ACP1 gene is also a risk factor of CAD in Han Chinese females aged 65 years and older. View Full-Text
Keywords: coronary artery disease; SNP; PTPN11; PHACTR11; ACP1; meta-analysis coronary artery disease; SNP; PTPN11; PHACTR11; ACP1; meta-analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Han, X.; Zhang, L.; Zhang, Z.; Zhang, Z.; Wang, J.; Yang, J.; Niu, J. Association between Phosphatase Related Gene Variants and Coronary Artery Disease: Case-Control Study and Meta-Analysis. Int. J. Mol. Sci. 2014, 15, 14058-14076.

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