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Int. J. Mol. Sci. 2014, 15(6), 9878-9893; doi:10.3390/ijms15069878
Review

SPECT and PET Serve as Molecular Imaging Techniques and in Vivo Biomarkers for Brain Metastases

1,* , 1
,
2
,
2
,
3,4
,
5
 and
6
1 Section of Nuclear Medicine and Health Physics, Department of Surgical and Biomedical Sciences, University of Perugia, Perugia 06100, Italy 2 Section of Nuclear Medicine, Department of Clinical and Experimental Medicine, University of Sassari, Sassari 07100, Italy 3 Department of Biomedicine and Prevention, University of Rome Tor Vergata, Roma 00133, Italy 4 IRCCS Neuromed Pozzilli, Pozzilli (Isernia) 86077, Italy 5 Department of Engineering, University of Perugia, Perugia 06100, Italy 6 Section of Radiotherapy Department of Surgical and Biomedical Sciences, University of Perugia, Perugia 06100, Italy
* Author to whom correspondence should be addressed.
Received: 30 March 2014 / Revised: 13 May 2014 / Accepted: 14 May 2014 / Published: 3 June 2014
(This article belongs to the Special Issue Brain Metastasis 2014)
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Abstract

Nuclear medicine techniques (single photon emission computerized tomography, SPECT, and positron emission tomography, PET) represent molecular imaging tools, able to provide in vivo biomarkers of different diseases. To investigate brain tumours and metastases many different radiopharmaceuticals imaged by SPECT and PET can be used. In this review the main and most promising radiopharmaceuticals available to detect brain metastases are reported. Furthermore the diagnostic contribution of the combination of SPECT and PET data with radiological findings (magnetic resonance imaging, MRI) is discussed.
Keywords: brain metastases; molecular imaging; PET; SPECT; MRI; fusion imaging brain metastases; molecular imaging; PET; SPECT; MRI; fusion imaging
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Palumbo, B.; Buresta, T.; Nuvoli, S.; Spanu, A.; Schillaci, O.; Fravolini, M.L.; Palumbo, I. SPECT and PET Serve as Molecular Imaging Techniques and in Vivo Biomarkers for Brain Metastases. Int. J. Mol. Sci. 2014, 15, 9878-9893.

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