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Int. J. Mol. Sci. 2014, 15(6), 9762-9779; doi:10.3390/ijms15069762
Article

Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury

1,†
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Received: 18 February 2013; in revised form: 16 March 2014 / Accepted: 22 May 2014 / Published: 30 May 2014
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Abstract: Idiopathic pulmonary fibrosis (IPF) is a progressing lethal disease with few clinically effective therapies. Corilagin is a tannin derivative which shows anti-inflammatory and antifibrotics properties and is potentiated in treating IPF. Here, we investigated the effect of corilagin on lung injury following bleomycin exposure in an animal model of pulmonary fibrosis. Corilagin abrogated bleomycin-induced lung fibrosis as assessed by H&E; Masson’s trichrome staining and lung hydroxyproline content in lung tissue. Corilagin reduced the number of apoptotic lung cells and prevented lung epithelial cells from membrane breakdown, effluence of lamellar bodies and thickening of the respiratory membrane. Bleomycin exposure induced expression of MDA, IKKα, phosphorylated IKKα (p-IKKα), NF-κB P65, TNF-α and IL-1β, and reduced I-κB expression in mice lung tissue or in BALF. These changes were reversed by high-dose corilagin (100 mg/kg i.p) more dramatically than by low dose (10 mg/kg i.p). Last, corilagin inhibits TGF-β1 production and α-SMA expression in lung tissue samples. Taken together, these findings confirmed that corilagin attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling. Corilagin may serve as a promising therapeutic agent for pulmonary fibrosis.
Keywords: pulmonary fibrosis; corilagin; NF-κB; apoptosis; TGF-β1 pulmonary fibrosis; corilagin; NF-κB; apoptosis; TGF-β1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, Z.; Guo, Q.-Y.; Zhang, X.-J.; Li, X.; Li, W.-T.; Ma, X.-T.; Ma, L.-J. Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury. Int. J. Mol. Sci. 2014, 15, 9762-9779.

AMA Style

Wang Z, Guo Q-Y, Zhang X-J, Li X, Li W-T, Ma X-T, Ma L-J. Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury. International Journal of Molecular Sciences. 2014; 15(6):9762-9779.

Chicago/Turabian Style

Wang, Zheng; Guo, Qiong-Ya; Zhang, Xiao-Ju; Li, Xiao; Li, Wen-Ting; Ma, Xi-Tao; Ma, Li-Jun. 2014. "Corilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury." Int. J. Mol. Sci. 15, no. 6: 9762-9779.



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