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Int. J. Mol. Sci. 2014, 15(5), 8941-8958; doi:10.3390/ijms15058941

Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain

1
Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Department of Plant Pathology, College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China
2
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China
3
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
*
Authors to whom correspondence should be addressed.
Received: 24 March 2014 / Revised: 2 May 2014 / Accepted: 5 May 2014 / Published: 20 May 2014
(This article belongs to the Section Biomaterial Sciences)
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Abstract

A series of 5-substituted-2-furoyl diacylhydazide derivatives with aliphatic chain were designed and synthesized. Their structures were characterized by IR, 1H NMR, elemental analysis, and X-ray single crystal diffraction. The anti-tumor bioassay revealed that some title compounds exhibited promising activity against the selected cancer cell lines, especially against the human promyelocytic leukemic cells (HL-60). Their fungicidal tests indicated that most of the title compounds showed significant anti-fungal activity. The preliminary structure-activity relationship showed that the aliphatic chain length and differences in the R2 group had obvious effects on the anti-tumor and anti-fungal activities. The bioassay results demonstrated that the title compounds hold great promise as novel lead compounds for further drug discovery. View Full-Text
Keywords: diacylhydrazide; aliphatic chain; synthesis; bioactivity diacylhydrazide; aliphatic chain; synthesis; bioactivity
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MDPI and ACS Style

Cui, Z.; Li, X.; Tian, F.; Yan, X. Synthesis and Bioactivity of 5-Substituted-2-furoyl Diacylhydazide Derivatives with Aliphatic Chain. Int. J. Mol. Sci. 2014, 15, 8941-8958.

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