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Int. J. Mol. Sci. 2014, 15(5), 7987-8003; doi:10.3390/ijms15057987

Endothelial Nitric Oxide Synthase (eNOS) 4b/a Gene Polymorphisms and Coronary Artery Disease: Evidence from a Meta-Analysis

Department of Geriatrics, the Second Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 25 March 2014 / Revised: 24 April 2014 / Accepted: 29 April 2014 / Published: 7 May 2014
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a polymorphism. Case-control, cohort or cross-sectional studies evaluating the association between eNOS 4b/a polymorphism and CAD susceptibility were systematically identified in PubMed up to 31 October 2013. Pooled odds ratios (OR) and corresponding 95% confidence intervals (CIs) were calculated to assess the association in overall and subgroup analyses. A total of 10,617 cases and 8302 controls from 37 studies were included in the study. The results of overall analysis revealed significant positive associations between CAD risk and eNOS 4b/a polymorphism in homozygote comparisons (OR = 1.47, 95% CI = 1.16–1.87), heterozygote comparisons (OR = 1.14, 95% CI = 1.02–1.27) and dominant models (OR = 1.18, 95% CI = 1.06–1.33). In subgroup analyses, similar associations were identified in African individuals, as determined using population-based source subgroups and noted in small-and-moderate sample size subgroups (case sample size or control sample size <500). The current meta-analysis revealed that eNOS 4b/a polymorphisms could be a risk factor for developing CAD, particularly in African populations and population-based subgroups. View Full-Text
Keywords: endothelial nitric oxide synthase (eNOS); coronary artery disease (CAD); polymorphism; meta-analysis endothelial nitric oxide synthase (eNOS); coronary artery disease (CAD); polymorphism; meta-analysis

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yang, Y.; Du, K.; Liu, Z.; Lu, X. Endothelial Nitric Oxide Synthase (eNOS) 4b/a Gene Polymorphisms and Coronary Artery Disease: Evidence from a Meta-Analysis. Int. J. Mol. Sci. 2014, 15, 7987-8003.

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