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Int. J. Mol. Sci. 2014, 15(5), 7064-7123; doi:10.3390/ijms15057064

Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s

1
Chemical Engineering Department, Polytechnic University of Catalonia, Av. Diagonal 647, E-08028 Barcelona, Spain
2
Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, 13 km. David Aghmashenebeli Alley, Tbilisi 0159, Georgia
*
Authors to whom correspondence should be addressed.
Received: 27 February 2014 / Revised: 31 March 2014 / Accepted: 31 March 2014 / Published: 25 April 2014
(This article belongs to the Special Issue Biodegradable Materials)

Abstract

Poly(alkylene dicarboxylate)s constitute a family of biodegradable polymers with increasing interest for both commodity and speciality applications. Most of these polymers can be prepared from biobased diols and dicarboxylic acids such as 1,4-butanediol, succinic acid and carbohydrates. This review provides a current status report concerning synthesis, biodegradation and applications of a series of polymers that cover a wide range of properties, namely, materials from elastomeric to rigid characteristics that are suitable for applications such as hydrogels, soft tissue engineering, drug delivery systems and liquid crystals. Finally, the incorporation of aromatic units and α-amino acids is considered since stiffness of molecular chains and intermolecular interactions can be drastically changed. In fact, poly(ester amide)s derived from naturally occurring amino acids offer great possibilities as biodegradable materials for biomedical applications which are also extensively discussed.
Keywords: poly(alkylene dicarboxylate)s; poly(ester amide)s; α-amino acid derivatives; bio-based polymers; carbohydrate derivatives; biodegradability; scaffolds; biomedical applications poly(alkylene dicarboxylate)s; poly(ester amide)s; α-amino acid derivatives; bio-based polymers; carbohydrate derivatives; biodegradability; scaffolds; biomedical applications
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Díaz, A.; Katsarava, R.; Puiggalí, J. Synthesis, Properties and Applications of Biodegradable Polymers Derived from Diols and Dicarboxylic Acids: From Polyesters to Poly(ester amide)s. Int. J. Mol. Sci. 2014, 15, 7064-7123.

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