Hypoxic Signaling During Tissue Repair and Regenerative Medicine
AbstractIn patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in wound healing, knowledge about the function of HIF-2α in wound healing is lacking. This review focuses on the function of HIF-1α and HIF-2α in microvascular network formation, wound healing, and therapy strategies. View Full-Text
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Nauta, T.D.; van Hinsbergh, V.W.M.; Koolwijk, P. Hypoxic Signaling During Tissue Repair and Regenerative Medicine. Int. J. Mol. Sci. 2014, 15, 19791-19815.
Nauta TD, van Hinsbergh VWM, Koolwijk P. Hypoxic Signaling During Tissue Repair and Regenerative Medicine. International Journal of Molecular Sciences. 2014; 15(11):19791-19815.Chicago/Turabian Style
Nauta, Tessa D.; van Hinsbergh, Victor W.M.; Koolwijk, Pieter. 2014. "Hypoxic Signaling During Tissue Repair and Regenerative Medicine." Int. J. Mol. Sci. 15, no. 11: 19791-19815.