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Int. J. Mol. Sci. 2014, 15(10), 18381-18406; doi:10.3390/ijms151018381

Glycemic Variability and Oxidative Stress: A Link between Diabetes and Cardiovascular Disease?

Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Received: 26 August 2014 / Revised: 16 September 2014 / Accepted: 28 September 2014 / Published: 13 October 2014
(This article belongs to the Special Issue Oxidative Stress in Cardiovascular Disease 2015)
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Abstract

Diabetes is associated with a two to three-fold increase in risk of cardiovascular disease. However, intensive glucose-lowering therapy aiming at reducing HbA1c to a near-normal level failed to suppress cardiovascular events in recent randomized controlled trials. HbA1c reflects average glucose level rather than glycemic variability. In in vivo and in vitro studies, glycemic variability has been shown to be associated with greater reactive oxygen species production and vascular damage, compared to chronic hyperglycemia. These findings suggest that management of glycemic variability may reduce cardiovascular disease in patients with diabetes; however, clinical studies have shown conflicting results. This review summarizes the current knowledge on glycemic variability and oxidative stress, and discusses the clinical implications. View Full-Text
Keywords: glycemic variability; oxidative stress; diabetes; cardiovascular disease; hypoglycemia glycemic variability; oxidative stress; diabetes; cardiovascular disease; hypoglycemia
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Saisho, Y. Glycemic Variability and Oxidative Stress: A Link between Diabetes and Cardiovascular Disease? Int. J. Mol. Sci. 2014, 15, 18381-18406.

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