Int. J. Mol. Sci. 2013, 14(7), 14333-14345; doi:10.3390/ijms140714333
Article

Fluvastatin Influences Hair Color in C57Bl/6 Mice

* email, email, email and email
Received: 13 April 2013; in revised form: 25 June 2013 / Accepted: 1 July 2013 / Published: 10 July 2013
View Full-Text   |   Download PDF [580 KB, uploaded 19 June 2014]
Abstract: Our recent in vitro experiments suggest that fluvastatin may influence tyrosinase (key enzyme of melanogenesis) synthesis. The aim of the present study was to verify those findings in experiments, in vitro, in melanoma cell line, and in vivo, in mice. The expression of tyrosinase in B16F10 melanoma cell line, after induction of melanogenesis by UVB irradiation, was examined by Western blot analysis. Afterwards, the effect of fluvastatin on melanin synthesis in hair follicles of C57Bl/6 mice was investigated. The expression of tyrosinase was reduced in the presence of fluvastatin. In mice after anagen induction over the dorsal skin, gel containing fluvastatin in various concentrations was injected subcutaneously, while in part of control groups of mice, gel with placebo was injected. In addition, gel with fluvastatin was injected to four week-old mice (mice in first postnatal anagen) without anagen induction. In extension, injections of gel with fluvastatin or placebo were performed in mice without anagen induction (but after first postnatal anagen). In part of study group of mice (mice after anagen induction and injection of fluvastatin) regrowth of depigmented hair was observed, while in all control groups (mice after injection of placebo), such hair depigmentation over the skin area was not found. In conclusion, this study, for the first time, shows that fluvastatin might affect melanin synthesis in vivo.
Keywords: fluvastatin; melanogenesis; melanoma; mice; statins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Galus, R.; Włodarski, K.; Malejczyk, J.; Jóźwiak, J. Fluvastatin Influences Hair Color in C57Bl/6 Mice. Int. J. Mol. Sci. 2013, 14, 14333-14345.

AMA Style

Galus R, Włodarski K, Malejczyk J, Jóźwiak J. Fluvastatin Influences Hair Color in C57Bl/6 Mice. International Journal of Molecular Sciences. 2013; 14(7):14333-14345.

Chicago/Turabian Style

Galus, Ryszard; Włodarski, Krzysztof; Malejczyk, Jacek; Jóźwiak, Jarosław. 2013. "Fluvastatin Influences Hair Color in C57Bl/6 Mice." Int. J. Mol. Sci. 14, no. 7: 14333-14345.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert