Int. J. Mol. Sci. 2013, 14(6), 10727-10748; doi:10.3390/ijms140610727
Review

The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding

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Received: 1 April 2013; in revised form: 9 May 2013 / Accepted: 9 May 2013 / Published: 23 May 2013
(This article belongs to the Special Issue Protein Folding 2015)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Poly-(R)-3-hydroxybutyrate (PHB), a linear polymer of R-3-hydroxybutyrate (R-3HB), is a fundamental constituent of biological cells. Certain prokaryotes accumulate PHB of very high molecular weight (10,000 to >1,000,000 residues), which is segregated within granular deposits in the cytoplasm; however, all prokaryotes and all eukaryotes synthesize PHB of medium-chain length (~100–200 residues) which resides within lipid bilayers or lipid vesicles, and PHB of short-chain length (<12 residues) which is conjugated to proteins (cPHB), primarily proteins in membranes and organelles. The physical properties of cPHB indicate it plays important roles in the targeting and folding of cPHB-proteins. Here we review the occurrence, physical properties and molecular characteristics of cPHB, and discuss its influence on the folding and structure of outer membrane protein A (OmpA) of Escherichia coli.
Keywords: poly-(R)-3-hydroxybutyrate; cPHB; PHBylation; protein-folding; protein-targeting
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MDPI and ACS Style

Reusch, R.N. The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding. Int. J. Mol. Sci. 2013, 14, 10727-10748.

AMA Style

Reusch RN. The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding. International Journal of Molecular Sciences. 2013; 14(6):10727-10748.

Chicago/Turabian Style

Reusch, Rosetta N. 2013. "The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding." Int. J. Mol. Sci. 14, no. 6: 10727-10748.

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