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The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding
Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, USA
Received: 1 April 2013; in revised form: 9 May 2013 / Accepted: 9 May 2013 / Published: 23 May 2013
Abstract: Poly-(R)-3-hydroxybutyrate (PHB), a linear polymer of R-3-hydroxybutyrate (R-3HB), is a fundamental constituent of biological cells. Certain prokaryotes accumulate PHB of very high molecular weight (10,000 to >1,000,000 residues), which is segregated within granular deposits in the cytoplasm; however, all prokaryotes and all eukaryotes synthesize PHB of medium-chain length (~100–200 residues) which resides within lipid bilayers or lipid vesicles, and PHB of short-chain length (<12 residues) which is conjugated to proteins (cPHB), primarily proteins in membranes and organelles. The physical properties of cPHB indicate it plays important roles in the targeting and folding of cPHB-proteins. Here we review the occurrence, physical properties and molecular characteristics of cPHB, and discuss its influence on the folding and structure of outer membrane protein A (OmpA) of Escherichia coli.
Keywords: poly-(R)-3-hydroxybutyrate; cPHB; PHBylation; protein-folding; protein-targeting
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MDPI and ACS Style
Reusch, R.N. The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding. Int. J. Mol. Sci. 2013, 14, 10727-10748.
Reusch RN. The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding. International Journal of Molecular Sciences. 2013; 14(6):10727-10748.
Reusch, Rosetta N. 2013. "The Role of Short-Chain Conjugated Poly-(R)-3-Hydroxybutyrate (cPHB) in Protein Folding." Int. J. Mol. Sci. 14, no. 6: 10727-10748.