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A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan
Department of Gynecology, Ohki Memorial Kikuchi Cancer Clinic for Women, Tokorozawa, Saitama 3591133, Japan
* Author to whom correspondence should be addressed.
Received: 17 February 2013; in revised form: 11 March 2013 / Accepted: 12 March 2013 / Published: 15 March 2013
Abstract: Ovarian cancer treatment presently does not reflect molecular differences in histologic subtype. Ovarian clear cell carcinoma (OCCC) exhibits several differences in terms of molecular pathogenesis and tumor behavior from the more common, chemosensitive, serous carcinomas, which makes OCCC a candidate for targeted therapies. A 53-year-old Japanese woman was diagnosed with stage IIIc ovarian clear cell adenocarcinoma with marked chemoresistance to conventional regimens. She demonstrated a partial response to a multikinase inhibitor. The tumor was resistant to PI3K/mTOR pathway inhibitors despite harboring a PIK3CA mutation. The present case suggests a role for targeted therapies in the treatment of OCCC and a need for the identification of biomarkers that will predict response to targeted therapies.
Keywords: ovarian clear cell carcinoma; biomarkers; PIK3CA; mTOR inhibitor
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Rahman, M.; Nakayama, K.; Ishibashi, T.; Ishikawa, M.; Rahman, M.T.; Katagiri, H.; Katagiri, A.; Iida, K.; Kikuchi, Y.; Miyazaki, K. A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies. Int. J. Mol. Sci. 2013, 14, 6067-6073.
Rahman M, Nakayama K, Ishibashi T, Ishikawa M, Rahman MT, Katagiri H, Katagiri A, Iida K, Kikuchi Y, Miyazaki K. A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies. International Journal of Molecular Sciences. 2013; 14(3):6067-6073.
Rahman, Munmun; Nakayama, Kentaro; Ishibashi, Tomoka; Ishikawa, Masako; Rahman, Mohammed T.; Katagiri, Hiroshi; Katagiri, Atsuko; Iida, Kouji; Kikuchi, Yoshihiro; Miyazaki, Kohji. 2013. "A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies." Int. J. Mol. Sci. 14, no. 3: 6067-6073.