Int. J. Mol. Sci. 2013, 14(3), 4476-4497; doi:10.3390/ijms14034476
Review

From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A

1,2,* email, 1,2,3email and 1,3email
Received: 16 January 2013; in revised form: 5 February 2013 / Accepted: 15 February 2013 / Published: 25 February 2013
(This article belongs to the Special Issue Recent Advances in the Research of Multiple Sclerosis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals, probably triggered by common environmental factors. Human leukocyte antigen (HLA) loci were early shown to confer the strongest genetic associations in MS. Now, more than 50 non-HLA MS susceptibility loci are identified, of which the majority are located in immune-regulatory genes. Single nucleotide polymorphisms (SNPs) in the C-type lectin-like domain family 16A (CLEC16A) gene were among the first non-HLA genetic variants that were confirmed to be associated with MS. Fine-mapping has indicated a primary association in MS and also other autoimmune diseases to intronic CLEC16A SNPs. Here, we review the identification of MS susceptibility variants in the CLEC16A gene region, functional studies of the CLEC16A molecule and the recent progress in understanding the implications thereof for MS development. This may serve as an example of the importance for further molecular investigation of the loci identified in genetic studies, with the aim to translate this knowledge into the clinic.
Keywords: autoimmunity; multiple sclerosis; CLEC16A; SOCS1; DEXI; CIITA
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MDPI and ACS Style

Berge, T.; Leikfoss, I.S.; Harbo, H.F. From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. Int. J. Mol. Sci. 2013, 14, 4476-4497.

AMA Style

Berge T, Leikfoss IS, Harbo HF. From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. International Journal of Molecular Sciences. 2013; 14(3):4476-4497.

Chicago/Turabian Style

Berge, Tone; Leikfoss, Ingvild S.; Harbo, Hanne F. 2013. "From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A." Int. J. Mol. Sci. 14, no. 3: 4476-4497.

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