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Expression and Functions of Fibroblast Growth Factor 10 in the Mouse Mammary Gland
Key Laboratory of Dairy Science of Ministry of Education, Northeast Agricultural University, Harbin 150030, China
* Author to whom correspondence should be addressed.
Received: 13 December 2012; in revised form: 15 January 2013 / Accepted: 5 February 2013 / Published: 18 February 2013
Abstract: Fibroblast growth factor 10 (FGF10) is important as a mesenchymal mediator of epithelial growth and morphogenesis. In this study, the expression and localization of the FGF10 protein were detected by laser scanning confocal microscopy during mouse postnatal mammary gland development. Mammary explants were cultured to investigate the functions of FGF10. The results revealed that FGF10 localizes mainly in the mesenchyme near the ductal epithelial cells and the alveolar epithelial cells of the mammary gland. Peak FGF10 expression levels were observed at lactation day 10. FGF10 induced FGFR2-IIIb expression in the mammary epithelium, except in virgin or pregnant mice. FGF10 promoted the proliferation of mammary gland epithelial cells and reduced apoptosis. FGF10 is important during the mouse mammary gland growth, development, and reconstruction, and its effects are mediated by FGFR2-IIIb.
Keywords: mouse; mammary gland; FGF10
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Cui, Y.; Li, Q. Expression and Functions of Fibroblast Growth Factor 10 in the Mouse Mammary Gland. Int. J. Mol. Sci. 2013, 14, 4094-4105.
Cui Y, Li Q. Expression and Functions of Fibroblast Growth Factor 10 in the Mouse Mammary Gland. International Journal of Molecular Sciences. 2013; 14(2):4094-4105.
Cui, Yingjun; Li, Qingzhang. 2013. "Expression and Functions of Fibroblast Growth Factor 10 in the Mouse Mammary Gland." Int. J. Mol. Sci. 14, no. 2: 4094-4105.