Int. J. Mol. Sci. 2013, 14(12), 23762-23773; doi:10.3390/ijms141223762
Article

Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives

1 Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia 2 Department of Chemistry, Faculty of Science, Alexandria University, P.O. Box 426-Ibrahimia, Alexandria 21321, Egypt 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 24 October 2013; in revised form: 12 November 2013 / Accepted: 18 November 2013 / Published: 5 December 2013
(This article belongs to the Section Green Chemistry)
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Abstract: A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3ai and 4ae are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%–99%).
Keywords: tandem Aldol-Michael reactions; MCRs; barbituric acid; aqueous media; green chemistry

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MDPI and ACS Style

Al-Majid, A.M.; Barakat, A.; AL-Najjar, H.J.; Mabkhot, Y.N.; Ghabbour, H.A.; Fun, H.-K. Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives. Int. J. Mol. Sci. 2013, 14, 23762-23773.

AMA Style

Al-Majid AM, Barakat A, AL-Najjar HJ, Mabkhot YN, Ghabbour HA, Fun H-K. Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives. International Journal of Molecular Sciences. 2013; 14(12):23762-23773.

Chicago/Turabian Style

Al-Majid, Abdullah M.; Barakat, Assem; AL-Najjar, Hany J.; Mabkhot, Yahia N.; Ghabbour, Hazem A.; Fun, Hoong-Kun. 2013. "Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives." Int. J. Mol. Sci. 14, no. 12: 23762-23773.

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