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A correction was published on 30 April 2014, see Int. J. Mol. Sci. 2014, 15(5), 7537-7538.

Int. J. Mol. Sci. 2013, 14(12), 23762-23773; doi:10.3390/ijms141223762
Article

Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives

1
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Received: 24 October 2013 / Revised: 12 November 2013 / Accepted: 18 November 2013 / Published: 5 December 2013
(This article belongs to the Section Green Chemistry)
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Abstract

A simple protocol, involving the green synthesis for the construction of novel bis-pyrimidine derivatives, 3ai and 4ae are accomplished by the aqueous diethylamine media promoted tandem Aldol-Michael reaction between two molecules of barbituric acid derivatives 1a,b with various aldehydes. This efficient synthetic protocol using an economic and environmentally friendly reaction media with versatility and shorter reaction time provides bis-pyrimidine derivatives with high yields (88%–99%).
Keywords: tandem Aldol-Michael reactions; MCRs; barbituric acid; aqueous media; green chemistry tandem Aldol-Michael reactions; MCRs; barbituric acid; aqueous media; green chemistry
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Al-Majid, A.M.; Barakat, A.; AL-Najjar, H.J.; Mabkhot, Y.N.; Ghabbour, H.A.; Fun, H.-K. Tandem Aldol-Michael Reactions in Aqueous Diethylamine Medium: A Greener and Efficient Approach to Bis-Pyrimidine Derivatives. Int. J. Mol. Sci. 2013, 14, 23762-23773.

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