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Int. J. Mol. Sci. 2013, 14(12), 23441-23453; doi:10.3390/ijms141223441

Bone Morphogenetic Protein-7 Ameliorates Cerebral Ischemia and Reperfusion Injury via Inhibiting Oxidative Stress and Neuronal Apoptosis

Department of Neurology, Affiliated Hospital of Medical College Qingdao University, Qingdao 266003, Shandong, China
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Author to whom correspondence should be addressed.
Received: 21 September 2013 / Revised: 12 November 2013 / Accepted: 19 November 2013 / Published: 28 November 2013
(This article belongs to the Collection Programmed Cell Death and Apoptosis)
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Abstract

Previous studies have indicated that bone morphogenetic protein-7 (BMP-7) is neuroprotective against cerebral ischemia/reperfusion (IR) injury. The present study was undertaken to determine the molecular mechanisms involved in this effect. Adult male Wistar rats were subjected to 2 h of transient middle cerebral artery occlusion (MCAO), followed by 24 h of reperfusion. BMP-7 (10−4 g/kg) or vehicle was infused into rats at the onset of reperfusion via the tail vein. Neurological deficits, infarct volume, histopathological changes, oxidative stress-related biochemical parameters, neuronal apoptosis, and apoptosis-related proteins were assessed. BMP-7 significantly improved neurological and histological deficits, reduced the infarct volume, and decreased apoptotic cells after cerebral ischemia. BMP-7 also markedly enhanced the activities of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and reduced the level of malondialdehyde (MDA) in IR rats. In addition, Western blot analysis indicated that BMP-7 prevented cytochrome c release, inhibited activation of caspase-3, caspase-9 and caspase-8. Our data suggested that BMP-7 has protective effects against cerebral IR injury in rats, and the neuroprotective effects may be attributed to attenuating oxidative stress and inhibiting neuronal apoptosis. View Full-Text
Keywords: bone morphogenetic protein-7; cerebral ischemia/reperfusion injury; oxidative stress; apoptosis bone morphogenetic protein-7; cerebral ischemia/reperfusion injury; oxidative stress; apoptosis
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MDPI and ACS Style

Pei, H.; Cao, D.; Guo, Z.; Liu, G.; Guo, Y.; Lu, C. Bone Morphogenetic Protein-7 Ameliorates Cerebral Ischemia and Reperfusion Injury via Inhibiting Oxidative Stress and Neuronal Apoptosis. Int. J. Mol. Sci. 2013, 14, 23441-23453.

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