Abstract: Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
Keywords: community-acquired pneumonia; YKL-40; severity
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Wang, H.-L.; Hsiao, P.-C.; Tsai, H.-T.; Yeh, C.-B.; Yang, S.-F. Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients. Int. J. Mol. Sci. 2013, 14, 22817-22825.
Wang H-L, Hsiao P-C, Tsai H-T, Yeh C-B, Yang S-F. Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients. International Journal of Molecular Sciences. 2013; 14(11):22817-22825.
Wang, Hsiang-Ling; Hsiao, Pei-Ching; Tsai, Hsiu-Ting; Yeh, Chao-Bin; Yang, Shun-Fa. 2013. "Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients." Int. J. Mol. Sci. 14, no. 11: 22817-22825.