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Int. J. Mol. Sci. 2013, 14(11), 22817-22825; doi:10.3390/ijms141122817
Article

Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients

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Received: 7 August 2013; in revised form: 28 October 2013 / Accepted: 12 November 2013 / Published: 19 November 2013
(This article belongs to the Section Molecular Pathology)
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Abstract: Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
Keywords: community-acquired pneumonia; YKL-40; severity community-acquired pneumonia; YKL-40; severity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, H.-L.; Hsiao, P.-C.; Tsai, H.-T.; Yeh, C.-B.; Yang, S.-F. Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients. Int. J. Mol. Sci. 2013, 14, 22817-22825.

AMA Style

Wang H-L, Hsiao P-C, Tsai H-T, Yeh C-B, Yang S-F. Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients. International Journal of Molecular Sciences. 2013; 14(11):22817-22825.

Chicago/Turabian Style

Wang, Hsiang-Ling; Hsiao, Pei-Ching; Tsai, Hsiu-Ting; Yeh, Chao-Bin; Yang, Shun-Fa. 2013. "Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients." Int. J. Mol. Sci. 14, no. 11: 22817-22825.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert