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Int. J. Mol. Sci. 2013, 14(11), 22817-22825; doi:10.3390/ijms141122817
Article

Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients

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3,4
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3,6,7,*  and 1,8,*
1 Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan 2 Department of Beauty Science, National Taichung University of Science and Technology, Taichung 402, Taiwan 3 School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan 4 Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan 5 School of Nursing, Chung Shan Medical University, Taichung 402, Taiwan 6 Department of Emergency Medicine, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan 7 Department of Emergency Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan 8 Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
* Authors to whom correspondence should be addressed.
Received: 7 August 2013 / Revised: 28 October 2013 / Accepted: 12 November 2013 / Published: 19 November 2013
(This article belongs to the Section Molecular Diagnostics)
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Abstract

Plasma YKL-40 level has been reported as playing a significant role in community-acquired pneumonia (CAP). However, the correlation between plasma level of YKL-40 and the severity of CAP has not been reported. This study identifies the relationship between plasma level changes of the YKL-40 gene in adult patients hospitalized with CAP. The ELISA was used to measure the plasma YKL-40 level from 61 adult CAP patients before and after antibiotic treatment and from 60 healthy controls. The plasma YKL-40 levels were significantly increased in patients with CAP compared to normal controls. Moreover, the plasma concentration of YKL-40 correlated with the severity of CAP based on the pneumonia severity index (PSI) score (r = 0.630, p < 0.001), the CURB-65 (confusion, uremia, respiratory rate, BP, age 65 years) score (r = 0.640, p < 0.001), the Acute Physiology And Chronic Health Evaluation II (APACHE II) score (r = 0.539, p < 0.001) and length of hospital stay (r = 0.321, p = 0.011), respectively. In conclusion, plasma YKL-40 may play a role in the diagnosis and clinical assessment of CAP severity, which could potentially guide the development of treatment strategies.
Keywords: community-acquired pneumonia; YKL-40; severity community-acquired pneumonia; YKL-40; severity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, H.-L.; Hsiao, P.-C.; Tsai, H.-T.; Yeh, C.-B.; Yang, S.-F. Usefulness of Plasma YKL-40 in Management of Community-Acquired Pneumonia Severity in Patients. Int. J. Mol. Sci. 2013, 14, 22817-22825.

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