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Int. J. Mol. Sci. 2013, 14(10), 19867-19890; doi:10.3390/ijms141019867
Review

Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis

1,2,* , 1
 and 1
Received: 26 August 2013; in revised form: 11 September 2013 / Accepted: 22 September 2013 / Published: 1 October 2013
(This article belongs to the Special Issue Non-Alcoholic Fatty Liver Disease Research)
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Abstract: Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose tissue. Obesity is considered a chronic low-grade inflammatory state and the liver has been recognized as being an “immunological organ”. The complex role of the immune system in the pathogenesis of NASH is currently raising great interest, also in view of the possible therapeutic potential of immunotherapy in NASH. This review focuses on the disturbances of the cells constituting the innate and adaptive immune system in the liver and in adipose tissue.
Keywords: non-alcoholic steatohepatitis (NASH); innate immunity; adaptive immunity; adipokines non-alcoholic steatohepatitis (NASH); innate immunity; adaptive immunity; adipokines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Vonghia, L.; Michielsen, P.; Francque, S. Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis. Int. J. Mol. Sci. 2013, 14, 19867-19890.

AMA Style

Vonghia L, Michielsen P, Francque S. Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis. International Journal of Molecular Sciences. 2013; 14(10):19867-19890.

Chicago/Turabian Style

Vonghia, Luisa; Michielsen, Peter; Francque, Sven. 2013. "Immunological Mechanisms in the Pathophysiology of Non-Alcoholic Steatohepatitis." Int. J. Mol. Sci. 14, no. 10: 19867-19890.



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