Int. J. Mol. Sci. 2012, 13(7), 8071-8085; doi:10.3390/ijms13078071
Article

Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives

1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University, 34755, Kayisdagi, Istanbul, Turkey 2 Department of Molecular Biology and Genetics, BilGen, Genetics and Biotechnology Research Center, Faculty of Science, Bilkent University, 06800, Bilkent, Ankara, Turkey
* Author to whom correspondence should be addressed.
Received: 18 May 2012; in revised form: 7 June 2012 / Accepted: 13 June 2012 / Published: 28 June 2012
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Abstract: A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5ag was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and 1H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines.
Keywords: 1-(4-chlorobenzhydryl)piperazine derivatives; cell proliferation; benzoyl chlorides; cytotoxicity; cancer

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MDPI and ACS Style

Yarim, M.; Koksal, M.; Durmaz, I.; Atalay, R. Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives. Int. J. Mol. Sci. 2012, 13, 8071-8085.

AMA Style

Yarim M, Koksal M, Durmaz I, Atalay R. Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives. International Journal of Molecular Sciences. 2012; 13(7):8071-8085.

Chicago/Turabian Style

Yarim, Mine; Koksal, Meric; Durmaz, Irem; Atalay, Rengul. 2012. "Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives." Int. J. Mol. Sci. 13, no. 7: 8071-8085.

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