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Int. J. Mol. Sci. 2012, 13(7), 8071-8085; doi:10.3390/ijms13078071
Article

Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives

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Received: 18 May 2012 / Revised: 7 June 2012 / Accepted: 13 June 2012 / Published: 28 June 2012
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Abstract

A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5ag was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and 1H nuclear magnetic resonance spectra. Cytotoxicity of the compounds was demonstrated on cancer cell lines from liver (HUH7, FOCUS, MAHLAVU, HEPG2, HEP3B), breast (MCF7, BT20, T47D, CAMA-1), colon (HCT-116), gastric (KATO-3) and endometrial (MFE-296) cancer cell lines. Time-dependent cytotoxicity analysis of compound 5a indicated the long-term in situ stability of this compound. All compounds showed significant cell growth inhibitory activity on the selected cancer cell lines.
Keywords: 1-(4-chlorobenzhydryl)piperazine derivatives; cell proliferation; benzoyl chlorides; cytotoxicity; cancer 1-(4-chlorobenzhydryl)piperazine derivatives; cell proliferation; benzoyl chlorides; cytotoxicity; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yarim, M.; Koksal, M.; Durmaz, I.; Atalay, R. Cancer Cell Cytotoxicities of 1-(4-Substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine Derivatives. Int. J. Mol. Sci. 2012, 13, 8071-8085.

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