Next Article in Journal
The Three Dimensional Quantitative Structure Activity Relationships (3D-QSAR) and Docking Studies of Curcumin Derivatives as Androgen Receptor Antagonists
Previous Article in Journal
Hedyotis diffusa Willd Inhibits Colorectal Cancer Growth in Vivo via Inhibition of STAT3 Signaling Pathway
Article Menu

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2012, 13(5), 6129-6137; doi:10.3390/ijms13056129

Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice

1
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China
2
Hangzhou Tea Research Institute, China COOP, Hangzhou 310016, China
3
Zhejiang Economic & Trade Polytechnic, Hangzhou 310018, China
4
College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
5
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
6
Institute of Cardio-Cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou 310035, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 27 February 2012 / Revised: 2 May 2012 / Accepted: 7 May 2012 / Published: 18 May 2012
View Full-Text   |   Download PDF [209 KB, uploaded 19 June 2014]

Abstract

The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P View Full-Text
Keywords: FTY720; type 1 diabetes (T1D); non-obese diabetic (NOD) mice; physiological indexes FTY720; type 1 diabetes (T1D); non-obese diabetic (NOD) mice; physiological indexes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chen, X.; Ye, S.; Zhang, S.; Li, J.; Zhu, H.; Zheng, G.; Lu, Y.; Wan, H. Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice. Int. J. Mol. Sci. 2012, 13, 6129-6137.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top