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Int. J. Mol. Sci. 2012, 13(5), 6129-6137; doi:10.3390/ijms13056129
Article

Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice

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Received: 27 February 2012; in revised form: 2 May 2012 / Accepted: 7 May 2012 / Published: 18 May 2012
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Abstract: The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P
Keywords: FTY720; type 1 diabetes (T1D); non-obese diabetic (NOD) mice; physiological indexes FTY720; type 1 diabetes (T1D); non-obese diabetic (NOD) mice; physiological indexes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, X.; Ye, S.; Zhang, S.; Li, J.; Zhu, H.; Zheng, G.; Lu, Y.; Wan, H. Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice. Int. J. Mol. Sci. 2012, 13, 6129-6137.

AMA Style

Chen X, Ye S, Zhang S, Li J, Zhu H, Zheng G, Lu Y, Wan H. Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice. International Journal of Molecular Sciences. 2012; 13(5):6129-6137.

Chicago/Turabian Style

Chen, Xiaoqiang; Ye, Sudan; Zhang, Shikang; Li, Jianrong; Zhu, Hongying; Zheng, Gaoli; Lu, Yin; Wan, Haitong. 2012. "Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice." Int. J. Mol. Sci. 13, no. 5: 6129-6137.


Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert