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Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice
College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China
Hangzhou Tea Research Institute, China COOP, Hangzhou 310016, China
Zhejiang Economic & Trade Polytechnic, Hangzhou 310018, China
College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China
Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China
Institute of Cardio-Cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou 310035, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 27 February 2012; in revised form: 2 May 2012 / Accepted: 7 May 2012 / Published: 18 May 2012
Abstract: The studies were performed to investigate the physiological characteristics of non-obese diabetic (NOD) mice treated with FTY720. At the age of 12 weeks, each mouse was fed with FTY720 or physiological saline once a day for 10 weeks running, and their blood glucose, weight, anti-GAD antibody and organ indexes were determined. No mouse in group FTY720 (NOD mice treated with FTY720) showed diabetic symptoms. The average content of serum anti-GAD antibody in group FTY720 decreased 48.75% (P < 0.01). It was concluded that the spleen, kidney and liver of NOD mice treated with FTY720 shriveled significantly in the progression of diabetes (P < 0.01 or P < 0.05). The body weight of group FTY720 mice was slightly lower than that of the model control (MC) group and these two groups both had less body weight than the normal control (NC) group (P
Keywords: FTY720; type 1 diabetes (T1D); non-obese diabetic (NOD) mice; physiological indexes
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Chen, X.; Ye, S.; Zhang, S.; Li, J.; Zhu, H.; Zheng, G.; Lu, Y.; Wan, H. Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice. Int. J. Mol. Sci. 2012, 13, 6129-6137.
Chen X, Ye S, Zhang S, Li J, Zhu H, Zheng G, Lu Y, Wan H. Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice. International Journal of Molecular Sciences. 2012; 13(5):6129-6137.
Chen, Xiaoqiang; Ye, Sudan; Zhang, Shikang; Li, Jianrong; Zhu, Hongying; Zheng, Gaoli; Lu, Yin; Wan, Haitong. 2012. "Effect of FTY720 on Some Physiological Indexes of Non-Obese Diabetic (NOD) Mice." Int. J. Mol. Sci. 13, no. 5: 6129-6137.