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Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice
Department of Hepatobiliary Oncology, Cancer Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou 510060, China
State Key Laboratory of Oncology in Southern China, Guangzhou 510060, China
Department of Pharmocology, Guangzhou Institute for Drug Control, 23 Xizeng Road, Liwan District, Guangzhou 510160, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 15 March 2012; in revised form: 27 April 2012 / Accepted: 28 April 2012 / Published: 9 May 2012
Abstract: The purpose of this study was to evaluate the antioxidant nature of tea polyphenol on S180 cells induced liver cancer in mice. In the present study, hepatocellular carcinoma was induced by tumor transplantation of liver in situ. The antitumor activity of tea polyphenol has been determined in vivo in hepatocellular carcinoma mice after treatment of drug (50, 100, 150 mg/kg body weight) by gavage for 20 days. Results showed that a significant increase in serum aspartate transaminase (AST), alkaline phosphatase (ALP), alanine aminotransfere (ALT), malondialdehyde (MDA) level, decrease in serum white blood cells (WBC), serum total protein (TP), albumin (ALB), A/G, tumor necrosis factor-α (TNF-α) and interferon-gamma (IFN-γ), liver reduced glutathione (GSH) levels were observed. In addition, the levels of enzymic and non-enzymic antioxidants were decreased when subjected to S180 cells induction. These altered enzyme levels were ameliorated significantly by administration of tea polyphenol at the concentration of 50, 100, 150 mg/kg body weight in drug-treated animals. These results indicate that the protective effect of tea polyphenol was associated with inhibition of MDA induced by S180 cells and to maintain the antioxidant enzyme levels.
Keywords: S180 cell; antioxidant; AST; mice; tea polyphenol; hepatocarcinoma
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Cui, B.-K.; Liu, S.; Li, S.-H.; Wang, J.; Wang, Q.-B.; Li, S.-P.; Lin, X.-J. Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice. Int. J. Mol. Sci. 2012, 13, 5571-5583.
Cui B-K, Liu S, Li S-H, Wang J, Wang Q-B, Li S-P, Lin X-J. Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice. International Journal of Molecular Sciences. 2012; 13(5):5571-5583.
Cui, Bo-Kang; Liu, Su; Li, Shu-Hong; Wang, Jun; Wang, Qi-Bo; Li, Sheng-Ping; Lin, Xiao-Jun. 2012. "Effect of Tea Polyphenol on Oxidative Injury in S180 Cells Induced Hepatocarcinoma Mice." Int. J. Mol. Sci. 13, no. 5: 5571-5583.